论文部分内容阅读
航天飞行实践证明失重对血液循环系统有明显的影响，可引起心血管功能失调和航天贫血症。在探讨失重性血循环紊乱机理时，研究者们多着重于研究失重血液动力学的影响，而忽视了血液流变性在其中的作用。我们认为了解失重对血液流变性的影响，对于阐明航天中心血管系统和血液系统变化的机理，制定有效的防护措施都有一定的作用。本实验观察了6名被试者在7天模拟失重实验（－6度头低位卧床）中，血粘度、纤维蛋白原、血细胞压积、红细胞聚集指数的变化，说明头低位卧床可引起血液流变性指标的明显改变。主要表现在卧床第3天和第6天中纤维蛋白原、高、中、低三个切变率下的血粘度和红细胞聚集指数的明显增加。血细胞压积有增高趋势．但与卧床前相比无明显差别。统计学多元相关法分析的结果表明血细胞压积的改变不是引起模拟失重血粘度升高的主要原因。模拟失望所引起红细胞聚集和纤维蛋白原增高是造成协粘度改变的重要因素。本实验结果进一步证实我们提出的“航天血瘀症”假设的正确性。
Space flight practice has shown that weightlessness has a significant effect on the circulatory system and can cause cardiovascular dysfunction and space anemia. In discussing the mechanism of disabling circulatory disorders, researchers focus more on the effects of weightless hemodynamics, neglecting the role of hemorrheology. We believe that understanding the effects of weightlessness on hemorrheology has a role to play in elucidating the mechanism of changes in the vascular and hematogenous systems of the space center and developing effective protective measures. In this study, we observed changes in blood viscosity, fibrinogen, hematocrit, and erythrocyte aggregation index in a seven day simulated weightlessness test (-6 ° head-lying bed rest) in six subjects, indicating that head-low bed rest may cause blood flow Significant changes in degeneration indicators. Mainly manifested in bed 3 days and 6 days in fibrinogen, high, medium and low three shear rate of blood viscosity and erythrocyte aggregation index increased significantly. Hematocrit has an increasing trend. But no significant difference compared with bedridden. The results of multivariate correlation analysis showed that the change of hematocrit was not the main reason that caused the increase of simulated blood viscosity. Simulated disappointment caused by erythrocyte aggregation and increased fibrinogen is caused by an important factor in changes in co-viscosity. The experimental results further confirm the correctness of our hypothesis of “space blood stasis syndrome”.