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目的：探讨人白血细胞系 Ｕ９３７的白血病抑制因子（ＬＩＦ）受体 α亚基因和 ｇｐ１３０亚基细胞内区与转录洛性因子 Ｓｔａｔ３的活性关系，旨在研究白血病细胞增殖和分化的机制。方法：用基因重组技术将２个基因在细胞内区截除（ｇｐ１９０ＥＸ，ｇｐ１３０ＥＸ），并分别?
Objective: To investigate the relationship between the activity of transmembrane protein Stat3 and the intracellular domain of leukemia inhibitory factor (LIF) receptor alpha and gp130 subunit of human white blood cell line U937 in order to study the mechanism of leukemia cell proliferation and differentiation. Methods: The two genes were cut off in the intracellular region (gp190EX, gp130EX) by gene recombination technique and respectively?