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目的:通过研究应用抗炎消瘿方治疗自身免疫性甲状腺炎(EAT),来观察其对EAT小鼠甲状腺激素及抗体水平的影响。方法:联合应用甲状腺球蛋白(TG)与弗氏完全佐剂复制EAT小鼠模型后,随机分为正常组、模型组、甲状腺素组、强的松组、雷公藤组、抗炎消瘿方大剂量、中剂量、小剂量组实验,采用放射免疫法检测EAT小鼠血清中甲状腺激素T3、T4、FT3、FT4及血清甲状腺抗体TGA、TMA水平。结果:模型组T3、T4、FT3、FT4、TGA、TMA都高于正常组,差异有统计学意义(P<0.01)。抗炎消瘿方大剂量组T3、T4、FT3、FT4、TGA、TMA都低于模型组,差异有统计学意义(P<0.01,P<0.05)。结论:抗炎消瘿方对自身免疫性甲状腺炎具有治疗效果,能剂量依赖性地抑制体液免疫。
Objective: To observe the effect of anti-inflammatory and anti-inflammatory prescriptions on thyroid hormones and antibody levels in EAT mice by treating autoimmune thyroiditis (EAT). Methods: EAT mouse model was induced by combination of thyroglobulin (TG) and complete Freund’s adjuvant, then randomly divided into normal group, model group, thyroxine group, prednisone group, triptolide group, High dose, middle dose and low dose group. Thyroid hormone T3, T4, FT3, FT4 and serum thyroid antibody TGA and TMA in serum of EAT mice were detected by radioimmunoassay. Results: The levels of T3, T4, FT3, FT4, TGA and TMA in the model group were significantly higher than those in the normal group (P <0.01). The levels of T3, T4, FT3, FT4, TGA and TMA in the high-dose anti-inflammatory Xiaoya Recipe group were lower than those in the model group, with statistical significance (P <0.01, P <0.05). Conclusion: The anti-inflammatory Xiaoya Recipe has a therapeutic effect on autoimmune thyroiditis and inhibits humoral immunity in a dose-dependent manner.