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目的对氩离子凝固术联合埃索美拉唑治疗Barrett食管(BE)近期疗效进行评价。方法选择40例BE患者,采用随机数字表法分为埃索美拉唑治疗组(单纯药物组)和氩离子凝固术联合埃索美拉唑治疗组(联合治疗组),2组基线资料均衡。3、6、12个月分别随访,对其临床症状缓解情况和消除与复发情况进行评价。结果 12个月联合治疗组治疗满意率明显高于单纯药物组(85.0%vs55.0%,P<0.05)。在联合治疗组中,氩离子凝固术对短段BE治愈率达100%,2例长段BE在6个月时复发;未出现严重溃疡、出血和穿孔等并发症。单纯药物组未见病灶消除。结论氩离子凝固术联合埃索美拉唑治疗BE是安全有效的治疗方法。
Objective To evaluate the short-term efficacy of argon plasma coagulation combined with esomeprazole in the treatment of Barrett’s esophagus (BE). Methods Forty patients with BE were randomly divided into esomeprazole group (simple drug group) and argon ion coagulation combined with esomeprazole group (combination group). The baseline data of two groups were balanced . The patients were followed up at 3, 6 and 12 months respectively to evaluate their clinical symptoms and their elimination and relapse. Results The satisfaction rate of the 12-month combination therapy group was significantly higher than that of the simple drug group (85.0% vs55.0%, P <0.05). In the combined treatment group, argon ionocoagulation achieved a 100% cure rate for short-segment BEs and two long-segment BEs relapsed at 6 months; no complications such as severe ulceration, bleeding, and perforation occurred. Pure drug group no lesions were eliminated. Conclusion Argon ion coagulation combined with esomeprazole in the treatment of BE is a safe and effective treatment.