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目的：比较奥曲肽与加压素治疗因肝硬化而致食管（食道）静脉曲张破裂出血的疗效。方法：３８例病人，男性２３例，女性１５例，年龄４５±ｓ１０ａ，病程５．８±１．２ａ，随机分为２组，２０例用奥曲肪０．１ｍｇ，１８例用加压素１０Ｕ分别加入生理盐水２０ｍＬ，ｉｖ，而后再分别用奥曲肽０．５ｍｇ和加压素４０Ｕ各加入５％葡萄糖液１０００ｍＬ，静脉滴注２４ｈ，观察止血率和副作用。结果：奥曲肽和加压素的止血有效率为８０％和７７％，而奥曲肽用后无明显副作用，后者却有明显的腹痛、头痛、胸闷、大便次数增加等副作用。结论：奥曲肽治疗因肝硬化而致食管静脉曲张破裂出血与加压素一样有效，但更安全。
OBJECTIVE: To compare the efficacy of octreotide and vasopressin in the treatment of esophageal (variceal) variceal bleeding due to liver cirrhosis. Methods: 38 patients, 23 males and 15 females, aged 45 ± s10a, duration of 5.8 ± 1.2a, were randomly divided into two groups, 20 patients with octreotide 0.1mg, 18 patients with vasopressin 10U were added to normal saline 20mL, iv, and then respectively octreotide 0.5mg and vasopressin 40U were added 5% glucose solution 1000mL, intravenous infusion 24h, observe the bleeding rate and side effects. Results: The hemostatic efficacies of octreotide and vasopressin were 80% and 77% respectively. There was no obvious side effect after octreotide administration, while the latter had obvious side effects such as abdominal pain, headache, chest tightness and increased stool frequency. CONCLUSIONS: Octreotide is as effective as vasopressin in treating esophageal variceal bleeding due to cirrhosis but is safer.