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Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n = 121) and non-CHD group (n = 97). All these patients eceived PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results :The PWV of right carotid to femoral artery(Rc-f), left carotid to femoral artery(Lc-f), right radial to carotid artery(Rc-r), left adial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9.31± 1.75 vs 7.60±1.59, P＜0. 01; 9.02±1.71 vs 7.52±1.50, P＜0.01; 8. 69±1.37 vs 8. 00±1.27, P＜0.01; 8.52±1.03 vs 8. 03±1.2, P＜0.01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC=0. 818), at the peak point of its ROC curve, the PWV was 8.32 m/s. PWV＞8.32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV＞8.32 m/s of RC-F is a valuable predictor of CHD.