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机体的免疫系统主要通过免疫应答与免疫耐受维持机体的免疫平衡。调节性T细胞(Regulatory T cells,Treg)通过选择性抑制作用在调节免疫耐受中发挥着非常重要的功能。自1995年Sakaguchi等首次发现清除天然CD4+CD25+Treg细胞可导致自身免疫疾病,而补充这种细胞又可以防止自身免疫
The body’s immune system mainly through the immune response and immune tolerance to maintain the body’s immune balance. Regulatory T cells (Tregs) play a very important role in the regulation of immune tolerance through selective inhibition. Sakaguchi and others first discovered in 1995 that the removal of native CD4 + CD25 + Treg cells can lead to autoimmune diseases, and supplementation of these cells in turn prevents autoimmunity