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同时检测了７２例原发性肺癌、３３例肺良性疾病和３５例健康人血清中总超氧化物歧化酶（Ｔ－ＳＯＤ）、铜锌超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ），锰超氧化物歧化酶（Ｍｎ－ＳＯＤ），铜蓝蛋白（ＣＰ）活力及尿酸（ＵＡ）含量。肺癌血清Ｍｎ－ＳＯＤ及ＵＡ水平显著高于肺良性疾病和健康组（Ｐ＜０．０１）。Ｍｎ－ＳＯＤ对肺癌诊断的敏感性为８６．１１％，特异性为９１．１８％，诊断正确率为８８．５７％。晚期肺癌患者Ｍｎ－ＳＯＤ活力高于早期病人（Ｐ＜０．０５），８例肺癌手术后Ｔ－ＳＯＤ及Ｍｎ－ＳＯＤ明显下降（Ｐ＜０．０１）。Ｍｎ－ＳＯＤ与ＵＡ并联检测敏感性为９４．４４％，特异性为８５．２９％，诊断正确率为９０％。Ｍｎ－ＳＯＤ、ＵＡ和ＣＰ全部测定时敏感性则为９７．２２％，特异性为７７．９４％，诊断正确率为８７．８６％。结果提示，肺癌患者血清氧自由基清除剂水平增高。对肺癌诊断、鉴别诊断、病情分析及手术疗效监测起重要作用。
At the same time, total superoxide dismutase (T-SOD) and copper-zinc superoxide dismutase (CuZn-SOD) in the serum of 72 patients with primary lung cancer, 33 patients with benign pulmonary disease, and 35 healthy individuals were detected. Dismutase (Mn-SOD), ceruloplasmin (CP) activity and uric acid (UA) content. The serum Mn-SOD and UA levels in lung cancer were significantly higher than those in benign lung disease and healthy group (P<0.01). The sensitivity of Mn-SOD in the diagnosis of lung cancer was 86.11%, the specificity was 91.18%, and the diagnostic accuracy was 88.57%. The Mn-SOD activity in patients with advanced lung cancer was higher than that in early patients (P<0.05), and the T-SOD and Mn-SOD were significantly decreased in 8 lung cancer patients after surgery (P<0.01). The sensitivity of detection of Mn-SOD and UA in parallel was 94.44%, specificity was 85.29%, and the diagnostic accuracy rate was 90%. The sensitivities of Mn-SOD, UA and CP were all 97.22%, the specificity was 77.94%, and the diagnostic accuracy was 87.86%. The results suggest that the serum oxygen free radical scavenger levels increase in patients with lung cancer. It plays an important role in lung cancer diagnosis, differential diagnosis, condition analysis and monitoring of surgical outcomes.