论文部分内容阅读
目的评价腹腔镜联合不同药物对不孕合并子宫内膜异位症患者妊娠结局的治疗效果。方法对242例子宫内膜异位症合并不孕症的患者行腹腔镜下外科手术,术后分别接受Gn RH-α方案、孕三烯酮胶囊和不用药等,分析比较3组患者术后症状缓解率、复发率、妊娠结局及不良反应等。结果 Gn RH-α组、孕三烯酮组的症状缓解率(分别为98.97%、97.09%)及妊娠率(分别为73.20%、70.87%)均明显高于对照组(分别为57.14%、35.71%),复发率(分别为24.74%、21.36%)均明显低于对照组(64.29%),差异均有统计学意义(P<0.05);Gn RH-α组、孕三烯酮组的自然分娩率(分别为27.84%、26.80%)高于对照组(3.09%),差异有统计学意义(P<0.05);3组的复发率均为Ⅲ~Ⅳ期明显高于Ⅰ~Ⅱ期;Gn RH-α组、孕三烯酮组妊娠率均为Ⅲ~Ⅳ期明显低于Ⅰ~Ⅱ期;孕三烯酮组的转氨酶升高、阴道出血发生率明显高于对照组,差异均有统计学意义(P<0.05)。结论腹腔镜术后联合药物治疗不孕伴子宫内膜异位症,可有效改善妊娠结局,减少复发和不良反应,优先选择Gn RH-α方案。
Objective To evaluate the therapeutic effect of laparoscopic combined with different drugs on pregnancy outcomes in infertility patients with endometriosis. Methods A total of 242 patients with endometriosis and infertility underwent laparoscopic surgery. After receiving Gn RH-α, gestrinone capsules and no medication respectively, the patients in the three groups were compared after operation Symptom relief rate, recurrence rate, pregnancy outcome and adverse reactions. Results The rate of symptom relief (98.97%, 97.09%) and pregnancy rate (73.20%, 70.87%, respectively) in Gn RH-α group and gestrinone group were significantly higher than those in control group (57.14%, 35.71% %), The relapse rate (24.74%, 21.36%, respectively) was significantly lower than that of the control group (64.29%), the difference was statistically significant (P <0.05) (27.84% and 26.80% respectively) were higher than those in the control group (3.09%) (P <0.05). The recurrence rates of the three groups were significantly higher than those of the stages I and II. Gn RH-α group, gestrinone group were Ⅲ ~ Ⅳ pregnancy rate was significantly lower than Ⅰ ~ Ⅱ; gestrinone group increased transaminases, the incidence of vaginal bleeding was significantly higher than the control group, the difference was Statistical significance (P <0.05). Conclusion Combined laparoscopic treatment of infertility with endometriosis can effectively improve the outcome of pregnancy and reduce the recurrence and adverse reactions, giving priority to the Gn RH-α regimen.