论文部分内容阅读
IL-33作为IL-1家族的新成员,具有双重作用,作为胞外炎症介质,当组织或细胞损伤时IL-33被释放,并与细胞膜上的受体ST2结合,激活胞内的信号通路,从而增强Th1细胞和Th2细胞反应,参与机体的多种微环境的免疫调节;作为核内DNA结合蛋白,调节蛋白质的合成。IL-33广泛分布于各组织中,参与炎症反应的各个阶段,其在病毒和多种寄生虫感染性疾病的作用研究中已取得重大突破,尤其在病毒性肝炎、单纯疱疹病毒感染和过敏性哮喘等疾病中具有重要作用;在寄生虫感染方面,如委内瑞拉粪类圆线虫、肠道线虫和杜氏利氏曼原虫等感染中,IL-33具有抑制炎症反应的作用。因此,现就IL-33在病毒和寄生虫方面的研究进行综述。
As a new member of the IL-1 family, IL-33 plays a dual role as an extracellular inflammatory mediator. IL-33 is released when tissues or cells are damaged, and binds to ST2 on the cell membrane to activate intracellular signaling , Thereby enhancing the Th1 cells and Th2 response, involved in the body’s immune regulation of a variety of microenvironment; as a nuclear DNA-binding protein, regulate protein synthesis. IL-33 is widely distributed in tissues and is involved in all stages of the inflammatory response and has made significant breakthroughs in the study of the role of viruses and various parasitic infectious diseases, particularly in viral hepatitis, herpes simplex virus infections and allergies Asthma and other diseases plays an important role in the parasitic infections, such as Venezuelan stool nematode, intestinal nematode and Duratus littoralis and other infections, IL-33 has an inhibitory effect on inflammation. Therefore, an overview of IL-33 research in viruses and parasites is now available.