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消化道癌症腹膜播散或并发癌性腹膜炎时,预后极恶,平均生命3～6个月。对腹膜浆膜面播散做抗癌治疗,始于1980年 Spatt 对胰癌腹膜播散的患者,在手术后将含有氨甲喋呤的42℃灌注液,进行腹腔内温热灌注。作者、Koga、Fujimura 等对腹膜播散的预防与治疗,是在胃切除术后立即采用加抗癌药物的腹腔内温热灌流治疗,现介绍如下。手术时,对原发灶及左上腹部进行广泛切除,同时切除部分结肠、摘除双侧卵巢,尽可能地将腹膜表面的转移灶摘除。术后暂时关闭腹腔,温热灌流装置的流入、流出管分别置于上腹部与 Douglas 凹陷处。灌流液流入与流出的温度分别为45～46℃及43～44℃。对温热灌流引起体温升高的处理,采用全身低温麻醉(见图).
Digestive tract peritoneal dissemination or complications of cancerous peritonitis, the prognosis is extremely evil, the average life of 3 to 6 months. The anti-cancer treatment of peritoneal serosal surface spread began in 1980 when Spatt spread peritoneum on pancreatic cancer. After the operation, 42°C perfusion solution containing methotrexate was intraperitoneally infused. The prevention and treatment of peritoneal dissemination by the author, Koga, Fujimura, etc., is performed immediately after gastrectomy by intraperitoneal warm perfusion with anti-cancer drugs, as described below. At the time of surgery, the primary tumor and the upper left abdomen were extensively resected. At the same time, part of the colon was removed and the bilateral ovaries were removed. The metastases on the peritoneal surface were removed as far as possible. The abdominal cavity was temporarily closed after surgery. The inflow and outflow tubes of the warm perfusion device were placed in the upper abdomen and Douglas depression, respectively. The inflow and outflow temperatures of the perfusate were 45-46°C and 43-44°C, respectively. For the treatment of hyperthermia caused by hyperthermia, whole-body hypothermic anaesthesia is used (see figure).