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肺炎链球菌的自然转化与其自身的染色体基因突变有着密切联系。研究发现 ,调控肺炎链球菌发生转化的关键基因是操纵子comCDE ,它调控肺炎链球菌产生感受态 ,从而能获取外源基因。comC的产物CSP可诱导基因comDE的表达 ,而comE可反过来诱导comC的表达。comAB有修饰和运输comC的转录及翻译产物的作用。ciaRH则有抑制comC表达的作用。comE可通过诱导comX表达 ,从而诱导一系列的基因表达使细菌发生转化。一些环境因素可影响肺炎链球菌自然转化的发生。氧气可通过基因nox调节肺炎链球菌的转化发生 ,其中可能有基因cia RH和MicAB的参与。Ca2 + 对其转化的影响可能是通过调节基因ciaRH而实现的。而pH值则可能是通过改变CSP的活性对转化进行调节。
The natural transformation of S. pneumoniae is closely linked to its own mutation of the chromosomal gene. The study found that the key gene regulating the transformation of Streptococcus pneumoniae is the operator comCDE, which regulates the production of Streptococcus pneumoniae competent, which can access to foreign genes. CSP, a product of comC, can induce the expression of the gene comDE, which in turn can induce the expression of comC. comAB has the function to modify and transport comC transcription and translation products. ciaRH has the effect of inhibiting the expression of comC. comE can induce bacterial transformation by inducing comX expression, thereby inducing a series of gene expression. Some environmental factors can affect the natural transformation of Streptococcus pneumoniae. Oxygen can regulate the transformation of S. pneumoniae through gene nox, of which genes cia RH and MicAB may participate. The effect of Ca2 + on its transformation may be through regulating the gene ciaRH. The pH value may be by changing the activity of CSP to regulate the transformation.