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[目的]探讨抗结核药物引起肝脏损害情况,通过临床干预以保证结核病人得到全程规则治疗。[方法]对出现肝功能异常的153例结核病人治疗情况进行回顾分析,分析不同程度肝功能损害的临床干预措施及效果。[结果]71例肝功能轻度异常患者在密切观察下继续原方案抗结核治疗,对82例ALT、AST、ALP均﹥2×正常高限的结核患者进行了临床干预后,其症状均出现不同程度的减轻或消失。[结论]在抗结核药物使用过程中,应加强对肝功能的监测,根据肝功能结果,采取不同的临床干预措施可以保证结核病人得到全程规则治疗。
[Objective] To investigate the liver damage caused by anti-tuberculosis drugs and to ensure the regular treatment of TB patients through clinical intervention. [Methods] A retrospective analysis was made on the treatment of 153 cases of tuberculosis patients with abnormal liver function, and the clinical intervention measures and effects of different degrees of liver dysfunction were analyzed. [Results] 71 patients with mild dysfunction of liver function underwent close observation of anti-TB treatment. The clinical symptoms of 82 tuberculosis patients with ALT, AST and ALP> 2 × normal high limit were observed after clinical intervention To varying degrees, reduce or disappear. [Conclusion] The monitoring of liver function should be strengthened in the process of using anti-TB drugs. According to the results of liver function, different clinical interventions can ensure the TB patients get the regular treatment.