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致突变物可以引起哺乳动物生殖细胞染色体畸变,往往不能再与异性生殖细胞结合,或结合后会出现胚胎早期吸收或胚胎死亡。显性致死突变试验就是根据这个原理来检验受试物是否具有致突变性,由于这种方
Mutagens can cause chromosomal aberrations in mammalian germ cells, often unable to bind to heterosexual germ cells, or early embryo uptake or embryo death after binding. Dominant death lethal test is based on this principle to test whether the test substance has mutagenicity, because of this side