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决定心肌梗塞预后的重要因素是心肌不可逆损伤的范围。鉴于局部心肌代谢的持久抑制能定量地反映其病理情况,作者采用放射性标记的心肌代谢基质作正电子发射断层显影(以下简称 PET),对心肌代谢的完整性进行非侵入性定量检查。该法要求被标记的基质和放射性标记物的转归能反映内生性代谢的改变。因而,应用与生理基质相同的放射性核素如~(11)C、~(15)O 和 ~(13)N。基质则采用脂肪酸。~(11)C-棕榈酸盐摄取减少代表持久缺血引起的心肌代谢障碍而不是灌注减少本身所引起。本文旨在探讨 PET
An important factor in determining the prognosis of myocardial infarction is the extent of irreversible myocardial damage. In view of the long-term inhibition of local myocardial metabolism can quantitatively reflect the pathological conditions, the authors use radiolabeled myocardial metabolic substrate for positron emission tomography (hereinafter referred to as PET), the integrity of myocardial metabolism by non-invasive quantitative examination. The law requires that the outcome of labeled substrates and radioactive labels reflect changes in endogenous metabolism. Thus, the same radionuclides as the physiological substrates such as ~ (11) C, ~ (15) O and ~ (13) N are applied. The matrix uses fatty acids. The decrease in 11C-palmitate uptake represents the myocardial metabolic disorder caused by persistent ischemia rather than the decrease in perfusion itself. This article aims to explore PET