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目的探讨注射用重组人白细胞介素 2 (IL 2 )、干扰素 γ(IFN γ)在体内对老年性慢性阻塞性肺疾病 (COPD)稳定期患者NK细胞活性的影响。方法对老年COPD稳定期患者IL 2、IFN γ治疗组各 30例以及健康老年组 30例的NK活性进行检测。结果老年性COPD患者稳定期NK细胞活性明显低于正常对照组 (P <0 .0 1) ;IL 2、IFN γ在体内能明显提高老年性COPD患者的NK活性。结论老年性COPD患者稳定期NK活性对IL 2、IFN γ有明显的依赖性 ;IL 2、IFN γ对老年性COPD患者稳定期NK活性有调控作用。
Objective To investigate the effects of recombinant human interleukin 2 (IL 2) and interferon γ (IFNγ) on NK cell activity in elderly patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods The NK activity of senile elderly patients with stable COPD in IL 2, 30 cases in IFN γ group and 30 healthy elderly patients were detected. Results The activity of NK cells in elderly patients with COPD was significantly lower than that of the normal controls (P <0.01). IL 2 and IFNγ significantly increased the NK activity in elderly COPD patients. Conclusion The steady-state NK activity in elderly patients with COPD has obvious dependence on IL 2 and IFN γ. IL 2 and IFN γ may regulate the steady-state NK activity in COPD patients with senile COPD.