论文部分内容阅读
目的探讨应用苯巴比妥早期干预对极低体重新生儿的脑保护作用。方法以出生时体重<1500g新生儿作为研究对象,随机分为两组:非干预组、苯巴比妥干预组。观察指标包括惊厥、喂养情况、死亡率、住院时间、CT改变、预后等,追踪观察1年以上。用卡方和t检验进行统计分析。结果苯巴比妥干预组在惊厥发生率上要明显低于非干预组;CT(或B超)改变非干预组在早期(1月以内)明显高于苯巴比妥干预组,而在3月左右时两组无明显差异;预后干预组要优于非干预组;喂养不耐受苯巴比妥干预组与非干预组相似;在死亡率和住院时间上两组无明显差异。结论应用苯巴比妥对极低体重新生儿早期干预治疗能有效地减少惊厥的发生率,并对早期脑损伤有一定保护作用,同时可以改善预后。但死亡率和住院时间等指标上两组无明显差异。
Objective To explore the neuroprotective effect of phenobarbital early intervention on very low birth weight infants. Methods Neonates weighing <1500g at birth were randomly divided into two groups: non-intervention group and phenobarbital intervention group. Observational indicators including convulsions, feeding, mortality, hospital stay, CT changes, prognosis, follow-up observation for more than 1 year. Statistical analysis using chi-square and t-test. Results Compared with non-intervention group, the incidence of convulsion in phenobarbital intervention group was significantly lower than that in non-intervention group. In CT (or B-ultrasound) non-intervention group, it was significantly higher than that in phenobarbital intervention group in early (within 1 month) There was no significant difference between the two groups in the month; the prognosis intervention group was better than the non-intervention group; Feeding intolerance phenobarbital intervention group was similar to the non-intervention group; There was no significant difference in mortality and hospitalization time between the two groups. Conclusion The application of phenobarbital early intervention in very low birth weight neonates can effectively reduce the incidence of convulsions and protect the early brain injury and improve the prognosis. However, there was no significant difference between the two groups in mortality and length of stay.