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目的通过监测住院患者感染病原菌分布及耐药特征，及时掌握医院耐药菌监测情况，指导临床合理应用抗菌药物。方法采用法国梅里埃微生物API软件鉴定系统及ATB药敏测试板同时对精神病专科医院2013年1月~2014年6月临床各科送检的标本进行菌株鉴定与药物敏感性试验检测，用WHONET5软件进行统计分析。结果共分离出282株病原菌，其中，革兰氏阴性菌150株占53.19%，革兰氏阳性菌117株占41.49%，真菌15株占5.32%。产ESBLs的大肠埃希菌，肺炎克雷伯菌对哌拉西林/三唑巴坦和碳青霉烯类敏感，MARS和MRCNS对夫西地酸、呋喃妥因、万古霉素均较敏感。结论医院应及时监测细菌耐药性情况，临床应重视病原菌检查及根据药敏合理选择应用抗菌药物，减少病原菌耐药的发生。“,”Objective According to analysis the distribution and drug resistance of pathogenic bacteria in Hospitalized patients,grasp the Monitoring situation of the Drug-resistant bacteria in hospital,guide pharmacists clinical rational administration.Methods By using method of The French bioMerieux microorganism API software evaluation system and ATB drug sensitive test,identified the strain and tested the drug sensitivity-al clinical samples (the psychiatric hospital from January 2012 to December 2013 year),used WHONET5 software for statistical analysis.Results A total of 282 strains of pathogens has isolated,.The 150 strains of gram negative bacteria accounted for 53.19%,117 gram positive bacteria accounted for 41.49%,15 strains of fungi accounted for 5.32%.ESBLs of Escherichia coli,ESBLs of Escherichia coli were sensitive to piperacil in,three tazobactam,carbopenems,MARS,MRCNS were sensitive to Fusidic acid,nitrofurantoin,vancomycin. Conclusion The hospital should be timely monitoring of bacterial drug resistance,clinical at ention should be paid to pathogenic bacteria and drug sensitivity test,according to the reasonable application of antibiotics,reduce the incidence of bacterial resistance.