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目的观察在社区医疗机构中应用口服降糖药物联合中效胰岛素治疗2型糖尿病的疗效。方法在对糖尿病患者进行饮食、运动、监测、教育等个性化指导基础上,采用中效胰岛素每晚睡前注射一次,原口服药物保持不变,每3天监测空腹血糖一次,根据空腹血糖结果调整口服药物和胰岛素用量,至血糖稳定,维持治疗。治疗前、治疗6个月对患者用药情况、血糖、糖化血红蛋白、血脂等检查指标进行综合分析评价。结果经过15～20天的调整,治疗剂量和治疗效果可以逐步达到稳定。随着血糖控制的稳定,血脂和糖化血红蛋白也显著改善。结论适时应用胰岛素联合口服药物治疗2型糖尿病,安全有效,是一项提高社区医疗机构诊治水平的有利措施。
Objective To observe the efficacy of oral hypoglycemic agents combined with moderate-acting insulin in community-based medical institutions in the treatment of type 2 diabetes mellitus. Methods On the basis of personalized guidance on diet, exercise, monitoring and education of diabetic patients, the patients were injected with mid-dose insulin at bedtime before bedtime, the original oral drug remained unchanged, and fasting blood glucose was monitored every 3 days. According to the results of fasting blood glucose Adjust oral medication and insulin dosage to stabilize blood sugar and maintain treatment. Before treatment, 6 months of treatment of patients with medication, blood glucose, glycosylated hemoglobin, blood lipids and other indicators of a comprehensive analysis and evaluation. Results After 15 to 20 days of adjustment, the treatment dose and treatment effect can be gradually stabilized. With steady-state glycemic control, blood lipids and HbA1c also improved significantly. Conclusions The timely application of insulin combined with oral medication for type 2 diabetes is safe and effective and is an advantageous measure to improve the diagnosis and treatment of community-based medical institutions.