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目的探讨新诊断2型糖尿病(T2DM)患者尿Smad3蛋白水平及其影响因素。方法选取新诊断T2DM患者68例,采用酶联免疫吸附法(ELISA)检测新诊断T2DM患者尿中Smad3蛋白水平,并测定患者的空腹血糖和血脂。按尿微量白蛋白分为正常白蛋白尿组(37例)和微量蛋白尿组(31例),比较两组患者中尿Smad3蛋白水平,采用相关和线性回归分析法分析新诊断T2DM患者尿Smad3蛋白的影响因素。结果与正常蛋白尿组比较,微量白蛋白尿组患者的空腹血糖、糖化血红蛋白(HbA1C)、总胆固醇、低密度脂蛋白胆固醇、血尿酸及尿Smad3蛋白水平均较高,差异均有统计学意义(P<0.05);新诊断T2DM患者尿Smad3蛋白与HbA1C、总胆固醇、血尿酸和尿微量白蛋白呈正相关;线性回归分析显示,HbA1C和尿微量白蛋白是新诊断T2DM患者尿Smad3蛋白的独立影响因素(β值分别为0.106、0.003,P<0.01,P<0.05)。结论尿Smad3蛋白水平可以作为新诊断T2DM患者肾脏损伤的一个评估指标。
Objective To investigate the urinary Smad3 protein level in newly diagnosed type 2 diabetes mellitus (T2DM) patients and its influencing factors. Methods Sixty-eight newly diagnosed T2DM patients were selected. Urinary protein levels of Smad3 in newly diagnosed T2DM patients were detected by enzyme-linked immunosorbent assay (ELISA), and fasting blood glucose and blood lipids were measured. Urine microalbuminuria was divided into normal albuminuria group (n = 37) and microalbuminuria group (n = 31). Urinary Smad3 protein levels in two groups were compared. Correlation and linear regression analysis were used to analyze urinary Smad3 Factors affecting protein. Results Compared with normal proteinuria group, the levels of fasting blood glucose, glycosylated hemoglobin (HbA1C), total cholesterol, low density lipoprotein cholesterol, serum uric acid and urinary Smad3 protein in patients with microalbuminuria were significantly higher, the difference was statistically significant (P <0.05). The urinary Smad3 protein in newly diagnosed T2DM patients was positively correlated with HbA1C, total cholesterol, serum uric acid and urine microalbumin. Linear regression analysis showed that HbA1C and urinary microalbumin were independent of urinary Smad3 protein in newly diagnosed T2DM patients Influencing factors (β values were 0.106, 0.003, P <0.01, P <0.05). Conclusion The urinary Smad3 protein level can be used as a new evaluation indicator of renal damage in newly diagnosed T2DM patients.