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[目的]观察补肾助孕组方人工周期联合枸橼酸氯米芬治疗多囊卵巢综合征不孕疗效。[方法]使用随机平行对照方法,将50例门诊患者按抽签法简单随机分为两组。对照组24例枸橼酸氯米芬片,50mg/次,1次/d;经期后第5d口服,连服5d。治疗组26例补肾助孕组方,西药治疗同对照组;经后期(卵泡期)-促卵泡汤(山茱萸、茯苓各15g,当归6g,白术炒、白芍炒、熟地、女贞子各12g,旱莲草15g,菟丝子30g,续断15g,仙茅、仙灵脾各20g,桑寄生、巴戟天、杜仲、覆盆子、补骨脂各15g,肉苁蓉、鹿角片先煎各10g,川牛膝、怀牛膝各12g,厚朴10g,甘草6g);月经第6d开始,1剂/d,连用5d,月经后第11~12d B超监测卵泡;经间期(排卵期)-促卵汤(促卵泡汤加路路通、赤芍各15g);卵泡发育至优势开始,1剂/d,连用2d,指导同房,第3d监测卵泡已排出,改用促黄体汤;卵泡未排且开始萎缩视为失败;经前期(黄体期)-促黄体汤(促卵泡汤去赤芍,鹿角片,加山药炒20g),B超监测卵泡已排出后用,卵泡萎缩继续服用,1剂/d,连用14d;行经期(月经期)-活血化瘀汤(桃仁12g,红花10g,当归6g,白术炒12g,赤芍15g,生地12g,月季花、泽兰各15g,益母草30g,三棱12g,莪术15g,皂角刺10g,路路通、王不留行各15g,桂枝、香附、广郁金、川芎、川牛膝、怀牛膝各12g,厚朴、苍术各10g,甘草6g);月经第ld用药,l剂/d,连用5d。连续治疗3个月经周期为1疗程。观测临床症状、优势卵泡直径、排卵日子宫内膜厚度、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈12例,无效14例,总有效率46.15%。对照组痊愈9例,无效15例,总有效率37.50%。治疗组疗效优于对照组,相关指标治疗组改善优于对照组(P<0.01)。[结论]补肾助孕组方人工周期联合枸橼酸氯米芬治疗多囊卵巢综合征不孕疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Bushenzhuxie prescription artificial cycle combined with clomiphene citrate in the treatment of polycystic ovary syndrome infertility. [Methods] Using randomized parallel control method, 50 outpatients were randomly divided into two groups randomly according to the lottery method. Control group, 24 cases of clomiphene citrate tablets, 50mg / time, 1 / d; menstrual after 5d orally, and even served 5d. The treatment group, 26 cases of kidney and pregnancy group, Western medicine treatment with the control group; the late (follicular phase) - follicular soup (dogwood, Poria 15g, Angelica 6g, Atractylodes fried, Radix Paeoniae Alba, Rehmannia each 12g , Eclipta prostrata 15g, Dodder 30g, Dipsacus 15g, Curculigo, Epimedium 20g, Sang parasitic, Morinda officinalis, Eucommia, raspberry, psoralen the 15g, Cistanche, deer antler first fried 10g, Sichuan Achyranthes bidentata, Achyranthes bidentata each 12g, Magnolia officinalis 10g, licorice 6g); menstruation 6d, 1 / d, once every 5d, 11 ~ 12d after menstruation B super-monitoring follicles; Follicular soup plus all the way, the red peony 15g); follicular development to the advantage of the beginning, 1 / d, once every 2d, to guide the same room, the first 3d monitoring follicles have been discharged, use to promote luteinizing soup; Began to shrink as a failure; premenstrual (luteal phase) - luteinizing soup (follicular soup to red peony root, antler tablets, add yam fried 20g), B-monitoring follicles have been used after the discharge, follicular atrophy continue to take 1 / d, continuous use 14d; menstrual period (menstrual period) - Huoxue Huayu Decoction (peach kernel 12g, saffron 10g, Angelica 6g, Atractylodes speculation 12g, red peony 15g, habitat 12g, rose, Zeeland each 15g, Motherwort 30g, Edge 12g, Curcuma 15g, saponin thorns 10g, Passepartout , The king does not leave the 15g, Guizhi, incense attached to the wide turmeric, Chuanxiong, Achyranthes, Achyranthes each 12g, Magnolia, Atractylodes each 10g, licorice 6g); menstrual ld medication, l d , Used in conjunction 5d. Continuous treatment of 3 menstrual cycle for a course of treatment. Observation of clinical symptoms, the dominant follicle diameter, ovulation endometrial thickness, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured 12 cases, 14 cases ineffective, the total effective rate 46.15%. The control group recovered 9 cases, 15 cases ineffective, the total effective rate was 37.50%. The curative effect of the treatment group was better than that of the control group, and the improvement of the relevant index treatment group was better than that of the control group (P <0.01). [Conclusion] Bushenzhuxue prescription artificial cycle combined with clomiphene citrate in the treatment of polycystic ovary syndrome infertility satisfactory results, no serious adverse reactions, it is worth promoting.