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目的分析格林-巴利综合征(GBS)患者早期临床特点和电生理学检查,并探讨其病情进展严重程度的相关因素。方法收集2006年4月至2010年9月在玉林市第二人民医院收治的GBS患者60例的临床资料,患者病情等级根据Hughs评分分组,针对患者发病时脑脊液的蛋白量、血清C-反应蛋白、双上肢F波出现率是否<50%等指标进行评估。结果该研究结果显示,重症患者较轻症患者发病年龄大,双下肢F波出现率≤50%,蛋白-细胞分离现象更明显,C-反应蛋白升高更明显。GBS患者双上肢F波出现频率异常,可能是GBS患者重要的或惟一的异常电生理客观指标,随病情好转,F波出现,提示患者传导功能恢复。结论存在发病年龄大,双下肢F波出现率≤50%,脑脊液蛋白和C-反应蛋白升高明显患者,临床医生应注意其呼吸和心脏的异常情况,以防患者出现呼吸衰竭及心搏骤停而危及生命。
Objective To analyze the early clinical features and electrophysiological examination of patients with Guillain-Barre Syndrome (GBS) and to explore the related factors of their severity. Methods The clinical data of 60 patients with GBS admitted in the Second People’s Hospital of Yulin City from April 2006 to September 2010 were collected. The severity of the disease was grouped according to the Hughs score. The levels of cerebrospinal fluid protein, serum C-reactive protein , Double upper limb F wave appearance rate <50% and other indicators were evaluated. Results The results of this study showed that severe patients with mild disease onset age, F wave incidence of lower extremities ≤ 50%, protein-cell separation was more obvious, C-reactive protein increased more significantly. The abnormal frequency of F wave in upper extremity of GBS patients may be an important or only objective indicator of abnormal electrophysiology in patients with GBS. With the improvement of patient’s condition, F wave appears, which indicates the conduction function recovery of patients. Conclusions There are age of onset, F wave incidence in both lower extremities ≤50%, cerebrospinal fluid protein and C-reactive protein increased significantly, clinicians should pay attention to their respiratory and cardiac abnormalities in patients with respiratory failure and cardiac arrest Stop and endanger life.