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生长抑制素是在丘脑下部的一种能抑制垂体生长激素分泌的多肽样物质,1972年Gui-llemin 在研究生长激素释放因子时,自羊的下丘脑成功地分离提纯出生长激素释放抑制激素(生长抑制素),生长抑制素具有强大的抑制生长激素分泌的能力。由于生长抑制素作用广泛,除抑制生长激素的分泌外,而且还能影响胰腺功能、胃肠道激素的分泌、胃肠道的运动与吸收以及催乳素、TSH、ACTH 等的分泌。兼备了神经内分泌、神经传递物、邻分泌(Pa-rahormone)与传统内分泌激素的多样作用,因而受到学者们越来越多的重视。一、生长抑制素的结构与血浆内生长抑制素样免疫活性物(SLI)生长抑制素由14个氨基酸所构成的多肽,其线型或环状结构具有
Somatostatin is a polypeptide-like substance in the hypothalamus that inhibits the secretion of pituitary ghrelin. In 1972, Gui-llemin successfully isolated and purified the somatostatin from the hypothalamus of sheep in the study of growth hormone releasing factor Somatostatin) has a strong ability to inhibit the secretion of growth hormone. Because of the wide range of somatostatin, in addition to inhibiting the secretion of growth hormone, but also affect the function of the pancreas, secretion of gastrointestinal hormones, gastrointestinal motility and absorption, and prolactin, TSH, ACTH secretion. Due to the diverse functions of neuroendocrine, neurotransmitter, Pa-rahormone and traditional endocrine hormones, scholars pay more and more attention. First, the structure of somatostatin and plasma endostatin-like immunologically active substance (SLI) Somatostatin peptide composed of 14 amino acids, the linear or cyclic structure has