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目的探讨卡托普利对接振家兔神经功能的影响及意义。方法将家兔分为接振组、干预组和对照组,对接振组和干预组进行接振试验,干预组从接振第11天起给予卡托普利。于接振试验前后对各组家兔进行体感诱发电位(SEP)及坐骨神经运动传导功能(MCF)的测定。结果接振组N1波、P1波、N2波的潜伏期分别为(30.76±4.26)、(41.91±6.67)、(45.29±5.81)ms,干预组分别为(27.00±3.04)、(35.07±4.20)、(41.15±3.19)ms。与接振试验前及试验后干预组、对照组比较,接振组SEP各波潜伏时明显延长,差异有统计学意义(P<0.05,P<0.01)。接振组坐骨神经运动传导速度、远端波幅、远端潜伏时分别为(35.69±4.37)ms、(1.55±0.73)μV、(8.16±0.71)ms,干预组分别为(52.20±5.13)ms、(2.89±0.36)μV、(7.26±0.77)ms。干预组较接振组坐骨神经运动传导速度、远端波幅明显延长,远端潜伏时均明显减小,差异均有统计学意义(P<0.01)。结论卡托普利对接振家兔神经功能的损伤有一定的改善作用。
Objective To investigate the effect and significance of captopril on nerve function in rabbits. Methods Rabbits were divided into receiving vibration group, intervention group and control group. The vibration of the vibration group and the intervention group were subjected to vibration test. The intervention group received captopril from the 11th day after vibration. Before and after the vibration test, the somatosensory evoked potential (SEP) and sciatic nerve conduction function (MCF) were measured in each group of rabbits. Results The latency of wave N1, wave P1 and wave N2 of the vibration group were (30.76 ± 4.26), (41.91 ± 6.67) and (45.29 ± 5.81) ms, respectively. The intervention group were (27.00 ± 3.04) and (35.07 ± 4.20) , (41.15 ± 3.19) ms. Compared with the intervention group and the control group before and after the vibration test, the waves of SEP in the vibration-receiving group obviously prolonged, the difference was statistically significant (P <0.05, P <0.01). The velocity, distal amplitude and distal latency of the sciatic nerve were (35.69 ± 4.37) ms and (1.55 ± 0.73) μV and (8.16 ± 0.71) ms, respectively, in the intervention group were (52.20 ± 5.13) ms and (2.89 ± 0.36) μV, (7.26 ± 0.77) ms. The velocity of the sciatic nerve conduction in the intervention group was significantly longer than that in the indirect vibration group, the amplitude of the distal end was significantly prolonged and the latency of the distal end was significantly reduced. The difference was statistically significant (P <0.01). Conclusions Captopril can improve the neurological function in rabbits.