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偏头痛发病机制尚未完全阐明,临床及实验室资料表明多巴胺受体超敏起一定作用。传统的多巴胺能受体激动剂—阿朴吗啡对非偏头痛患者无效的剂量可诱发偏头痛患者特征性疼痛及相关症状,如呵欠、恶心、呕吐、低血压及晕厥。小剂量阿朴吗啡对慢性偏头痛有效性的报导使我们考虑到连续皮下注射该药可帮助多巴胺系统脱敏。 25岁女性患者,病史3年,无先兆型偏头痛。发作性疼痛位于右眼及眶周,每月发作3～4次,每次持续24小时左右,疼痛很重,不能坚持工作,伴有恶心、呕吐、畏光声。平时乘车或船时伴有恶心、吐、出汗及低血压。各种预防性治疗均无效,接受试验前已一年未用药、血、尿常规、心电、脑电、颅骨X光片均
The pathogenesis of migraine has not been fully elucidated, and clinical and laboratory data suggest that dopamine receptor hypersensitivity plays a role. Traditional doses of dopamine receptor agonist apomorphine to non-migraine sufferers induce characteristic pain and related symptoms in migraine sufferers such as yawning, nausea, vomiting, hypotension and syncope. The availability of low-dose apomorphine for chronic migraine has led us to consider that continuous subcutaneous injections of the drug may help desensitize the dopamine system. 25 year old female patient, history 3 years, no aura migraine. Episodic pain in the right eye and periorbital, seizures 3 to 4 times per month, each lasting about 24 hours, the pain is heavy, can not insist on work, accompanied by nausea, vomiting, photophobia. Usually accompanied by car or boat with nausea, vomiting, sweating and hypotension. A variety of preventive treatment are ineffective, one year before the test to accept the drug, blood, urine, ECG, EEG, skull X-ray films were