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目的比较积极降压与标准降压对脑出血血肿周围继发神经元损伤的影响。方法选择2013年10月—2014年11月期间来郑州市第三人民医院连续入院的脑出血患者76例,随机将其分成标准组和积极组,每组38例。标准组按照美国心脏病协会2010年指南推荐的降压标准降压,积极组给予早期降压。观察两组患者各项指标变化。结果两组患者在血肿侧与对侧镜像区NAA/Cr下降比例、早期神经功能缺损变化、死亡/残疾率方面相比,差异无统计学意义(P>0.05)。结论积极降压和标准降压两种方法对脑出血血肿周围继发神经元损伤均无明显影响,并且对预后的影响也并不明显。
Objective To compare the effects of active antihypertensive drugs and standard antihypertensive drugs on secondary neuronal injury around ICH. Methods From October 2013 to November 2014, 76 consecutive patients with ICH admitted to Zhengzhou Third People’s Hospital were randomly divided into standard group and active group, with 38 patients in each group. The standard group was depressurized according to the antihypertensive standard recommended by the 2010 American Heart Association guidelines, and the active group was given an early step-down. The changes of each index in two groups were observed. Results There was no significant difference in the ratio of NAA / Cr reduction, changes of early neurological deficits and death / disability rate between the two groups on the hematoma side and contralateral mirror area (P> 0.05). Conclusion Both active antihypertensive treatment and standard antihypertensive treatment have no significant effect on secondary neuronal injury around ICH, and the effect on prognosis is not obvious either.