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目的 分析侵袭性垂体腺瘤的相关因素。 方法 85例垂体腺瘤患者 ,根据术中观察及瘤周围组织病理检查分为侵袭性垂体腺瘤组 (6 2例 ) ,非侵袭性垂体腺瘤组 (2 3例 )。对两组患者的临床特征、术前的影像学表现、术前术后血催乳素 (PRL)、生长素 (GH)水平的动态测定结果进行对比分析。 结果 侵袭性垂体腺瘤患者临床症状进展快 ,较多的出现颅神经功能缺失症状 ;影像学检查多显示为大腺瘤 ,颅底骨质受损率高 ,肿瘤呈多方向、不规则生长 ;MRI显示肿瘤侵袭到海绵窦的特异性指标为颈内动脉包绕。术前、术后的内分泌功能测定可以反应出功能性垂体腺瘤的肿瘤残余和复发。 结论 对患者的临床特征、影像学表现、动态内分泌功能测定的综合分析可以提高预测垂体腺瘤的侵袭性
Objective To analyze the related factors of invasive pituitary adenomas. Methods Eighty-five patients with pituitary adenoma were divided into invasive pituitary adenoma group (62 cases) and non-invasive pituitary adenoma group (23 cases) according to intraoperative observation and histopathology. The clinical features of the two groups of patients, preoperative imaging features, preoperative and postoperative serum prolactin (PRL), auxin (GH) levels of dynamic measurement results were compared. Results The clinical symptoms of patients with invasive pituitary adenomas progressed rapidly, and there were more symptoms of cranial nerve function loss. The imaging findings mostly showed large adenomas. The rate of skull base bone damage was high, and the tumors showed multiple directions and irregular growth. MRI shows that the specific indicator of tumor invasion to the cavernous sinus is internal carotid artery bypass. Preoperative and postoperative assessment of endocrine function can reflect the residual and recurrence of functional pituitary adenomas. Conclusion Comprehensive analysis of the clinical features, imaging features, and dynamic endocrine function of patients can improve the prediction of invasiveness of pituitary adenomas