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目的尝试红霉素抗胃食管反流(GER)治疗支气管哮喘,观察对哮喘患者肺通气功能的影响。方法58例支气管哮喘患者,随机分为对照组27例,观察组31例,均予常规平喘治疗。观察组加用红霉素(1.0,静滴,1次/日),对照组加用非大环内酯类抗生素及普瑞博思(10mg,3次/日)。两组疗程均为2周。治疗前后均予肺通气功能检测。样本均数的比较采用t检验。结果观察组及对照组治疗后肺通气功能指标显著高于治疗前(P<0.01)。治疗后观察组与对照组各项肺通气功能指标差异无显著性(P>0.05)。结论一定剂量的红霉素具有抗胃食管反流作用,可显著改变支气管哮喘患者肺通气功能。
Objective To try erythromycin anti-gastroesophageal reflux (GER) in the treatment of bronchial asthma and observe the effects of asthma on pulmonary function. Methods Fifty-eight patients with bronchial asthma were randomly divided into control group (n = 27) and observation group (n = 31). All patients were given routine asthma treatment. The observation group was given erythromycin (1.0, intravenous drip, once daily), while the control group was given non-macrolide antibiotics and pregabalin (10 mg, 3 times daily). Two groups of treatment are 2 weeks. Before and after treatment were pulmonary function tests. The sample mean comparison using t test. Results After the treatment, the pulmonary function indexes of the observation group and the control group were significantly higher than those before treatment (P <0.01). After treatment, there was no significant difference between the two groups (P> 0.05). Conclusion A certain dose of erythromycin has anti-gastroesophageal reflux effect, which can significantly change the pulmonary ventilation in patients with bronchial asthma.