论文部分内容阅读
背景与目的:放射性粒子植入对机体正常组织有何影响一直是临床关注的问题之一。本实验旨在分析放射性粒子125I植入在不同时间对正常家兔股动脉组织的影响。方法:选健康新西兰家兔30只,按每组10只分为三组,随机选取家兔一侧后腿股鞘切开直视下按术前TPS计划设计植入0.79～0.85mCi125I粒子10粒,在对照侧植入无放射活性空粒子10粒,分别在术后2周、2月及4月处死家兔,取出距离粒子植入部位最近的股动脉,分别进行大体观察、普通光镜观察以及电镜的超微结构观察。结果:三组实验兔大体观察放射性粒子植入侧血管无明显异常;普通光镜下可见少量内皮脱落;电镜下血管壁的改变主要为内皮细胞脱落,内皮细胞及平滑肌细胞变性,这种变性在所有内皮细胞中的比例,2周组为60%～70%,2月组约为50%左右,4月组在30%左右;变性的血管平滑肌细胞在所有平滑肌细胞中的比例,2周组为50%,2月组为30%,4月组为10%。结论:该实验剂量下放射性粒子125I对于正常动脉血管的影响以超微病理改变为主,而且这种损伤是可逆的。
BACKGROUND & OBJECTIVE: The effect of radioactive particle implantation on the normal tissues of the body has been one of the clinical concerns. The purpose of this experiment was to analyze the effect of 125I implantation of radioactive particles on femoral artery tissue of normal rabbits at different times. Methods: Thirty healthy New Zealand rabbits were selected and divided into three groups according to the group of ten. The rabbits were randomly selected to receive 0.79-0.85mCi125I particles , 10 rabbits without radioactive particles were implanted into the control group. Rabbits were sacrificed at 2 weeks, 2 months and 4 months after operation respectively. The femoral artery nearest to the site of particle implantation was removed for gross observation and general light microscopy Electron microscopy and ultrastructure observation. Results: There was no obvious abnormality of blood vessel in the three experimental rabbits. There was a small amount of endothelium shedding in the normal light microscope. The main changes of the vascular wall were the shedding of endothelial cells and the degeneration of endothelial cells and smooth muscle cells under the electron microscope The percentage of all endothelial cells was 60% -70% in 2 weeks group, about 50% in February group and about 30% in April group. The percentage of degenerative vascular smooth muscle cells in all smooth muscle cells, 50% in February, 30% in February and 10% in April. CONCLUSION: The effect of radioactive 125I on the normal arteries in this experimental dose is dominated by ultrastructural changes, and this injury is reversible.