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目的:探讨黄连碱对高脂饲料诱导的肥胖金黄地鼠的减肥作用及机制。方法:给予肥胖金黄地鼠黄连碱后,检测体重、肝重、脂体比和血脂等指标,观察其减肥效果。结果:给予黄连碱后,肥胖金黄地鼠的体重增长速度显著减缓,体脂含量降低;血清TC、TG、LDL-C水平明显降低,高剂量组HDLC水平显著提高,与模型组比较差异均具有统计学意义(P<0.05)。结论:黄连碱具有降脂减肥作用。
Objective: To investigate the effects of Coptis alkali on weight loss and mechanism of obesity golden hamster induced by high-fat diet. Methods: After giving obscurant golden hamster berberine, the body weight, liver weight, body fat ratio and blood lipid were measured to observe the effect of weight loss. Results: The body weight growth of obese golden hamster was significantly slowed down and the content of body fat was decreased after given rhizoma coptidis. The levels of serum TC, TG and LDL-C were significantly decreased, and the levels of HDLC in high dose group were significantly increased Statistical significance (P <0.05). Conclusion: Coptis alkaloid has lipid-lowering effect.