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目的:探讨艾司洛尔在先心病患儿术后快速型心律失常的适应证及使用剂量;观察艾司洛尔剂量与患儿血流动力学指标之间的关系。方法:对象为23例先心病术后室上性心动过速患儿,给予艾司洛尔静脉推注500μg/kg,15～30分钟后静脉滴注50～100μg(kg·min),观察其临床疗效。结果:所有患儿的心率均有不同程度的下降(从191bpm±28bpm至132bpm±18bpm,P<0.05),未出现低血压等副作用。用药后肝、肾功能无明显变化。结论:艾司洛尔可选择性地减慢心率,适用于小儿先心病术后出现的难治性室上速,用药剂量的选择与患儿的心功能状况有关。
OBJECTIVE: To investigate the indications and dosage of esmolol in children with congenital heart disease (AR) after tachyarrhythmia and observe the relationship between esmolol dose and hemodynamics in children. Methods: Twenty-three children with supraventricular tachycardia were enrolled in this study. Esmolol was injected intravenously at a dose of 500 μg / kg. After 15-30 minutes intravenous infusion of 50-100 μg (kg · min) was observed. Clinical efficacy. Results: All children had different degrees of heart rate decline (from 191bpm ± 28bpm to 132bpm ± 18bpm, P <0.05) and no side effects such as hypotension. After treatment of liver, kidney function no significant change. Conclusion: Esmolol can selectively slow heart rate and is suitable for refractory supraventricular tachycardia in children with congenital heart disease. The choice of dosage depends on the cardiac function of children.