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【目的】探讨急性胰腺炎（AP）患者血浆可溶性髓样细胞触发受体-1（sTREM-1）水平及其基因表达与其病情严重程度的关系。【方法】收集2011年8月至2013年8月本科收治的32例轻症急性胰腺炎（MAP）和25例重症急性胰腺炎（SAP）患者及10例健康志愿者作为研究对象。采用酶联免疫吸附法（ELISA）检测患者入科后d1、d3、d7血浆sTREM-1水平，采用反转录聚合酶链式反应（RT-PCR）检测TREM-1基因表达水平，并对患者的病情进行 APACHE Ⅱ与SOFA评分。【结果】MAP组入科后d1、d3、d7血浆sTREM-1浓度分别为（386．24±190．79）ng/L、（237．22±118．64）ng/L、（143．34±92．23）ng/L ；SAP组分别为（849．56±412．31）ng/L、（674．61±347．47）ng/L、（419．56±241．57）ng/L ，两组比较差异均有统计学意义（ P ＜0．01）。血浆 sTREM-1水平与 APACHE Ⅱ评分和 SOFA评分均呈正相关，相关系数分别为（ r ＝0．619，P ＜0．05和 r ＝0．610，P ＜0．05）。【结论】sTREM-1与 AP患者病情严重程度正相关，但SAP组TREM-1mRNA基因表达未见明显增加。“,”Objective To explore the relationship of plasma soluble myeloid cell triggering receptor-1 (sTREM-1) and gene expression with the severity of patients with acute pancreatitis .[Methods]A total of 32 patients with mild acute pancreatitis (MAP) ,25 patients with severe acute pancreatitis (SAP) and 10 healthy volunteers in our hospital from Aug .2011 to Aug .2013 were enrolled in the study .Enzyme-linked immu-nosorbent assay(ELISA) was used to detect plasma level of sTREM-1 at 1 ,3 and 7 days after admission .The expression of TREM-1 gene was examined by using reverse transcriptase polymerase chain reaction (RT-PCR) . APACHE Ⅱ and SOFA scores were used for assessing the condition of patients .[Results] Plasma levels of sTREM-1 in MAP group at 1 ,3 and 7 days after admission were (386 .24 ± 190 .79)ng/L ,(237 .22 ± 118 .64) ng /L and (143 .34 ± 92 .23)ng/L respectively ,and those in SAP group were (849 .56 ± 412 .31)ng/L , (674 .61 ± 347 .47)ng /L and (419 .56 ± 241 .57)ng/L respectively ,and there were significant differences be-tween two groups( P <0 .01) .Plasma levels of sTREM-1 were positively correlated with APACHE Ⅱ and SOFA score( r =0 .645 ,P <0 .05;r =0 .713 ,P <0 .05) .[Conclusion] Plasma levels of sTREM-1 is posi-tively correlated with the severity of patients with AP ,but the expression of TREM-1mRNA gene in SAP group is not increased .