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ＳＬＥ是一种主要累及育龄女性的自身免疫性疾病。在生育期的女性和男性中 ,ＳＬＥ发病率之比约为 9∶1 ,成年前和迟发ＳＬＥ的老年患者其比值却低得多。停经后首发ＳＬＥ的患者不常见 ,而且这类患者的疾病经过通常良好 ,提示雌激素状况可能在疾病的表现中起作用。小鼠ＳＬＥ模
SLE is an autoimmune disease that mainly affects women of childbearing age. In women and men of reproductive age, the incidence of SLE is approximately 9: 1, with much lower rates in older adults and those with late-onset SLE. Patients with SLE after menopause are uncommon and their disease is generally well-documented, suggesting that estrogen status may play a role in disease performance. Mouse SLE model