SURAMIN ACTIVIY IN HUMAN HEAD AND NECK SQUAMOUS CELL CARCINOMA——Ⅱ.EFFECT OF SURAMIN ON HUMAN HEAD AN

• 作 者: 李安太 王天铎 栾信庸 姜玉芳 G.A.M.S.Van Dongen B.J.M.Braakhuis G.B.Snow
• 机 构: Dept.of Otolaryngology Affiliated Hospital of Shandong Medical University,Dept.of Otolaryngology,Aff
• 出 处: 山东医科大学学报
• 发表日期: 1992年04期
• 关键词: nude antitumor squamous CELL toxicity lacking noted marked attenuated Amsterdam

In part Ⅰ of the study,we have demonstrated that suraminhas a marked antiproliferative effect on human head and neck squamous cellcarcinoma cell lines,In the present study,both toxicity and pharmacokineticstudies in nude mice were done.The treatment of nude mice bearing head andneck cancers with suramin showed that suramin had a minimal antitumor effect.The possible mechanism of suramin lacking antitumor effect is discussed.

In part I of the study, we have demonstrated that suraminhas a marked antiproliferative effect on human head and neck squamous cellcarcinoma cell lines,In the present study,both toxicity and pharmacokineticstudies in nude mice were done.The treatment of nude mice bearing head andneck cancers With suramin proved that suramin had a minimal antitumor effect.The possible mechanism of suramin lacking antitumor effect is discussed.