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应用流式细胞术对5例先天性中胚层肾瘤、96例肾母细胞瘤和27例正常肾石蜡包埋组织进行了DNA含量和增殖活性分析。同时进行组织学观察。结果表明,无论在出现非整倍体细胞峰上,还是DI值、S%、PI值上,先天性中胚层肾瘤与肾母细胞瘤比较均有显著性差异。由此提出了肾母细胞瘤流1式诊断标准与先天性中胚层肾瘤相鉴别。同时分析了临床造成误诊的主要原因。结合随访认为对出现DNA非整倍体的先天性中胚层肾瘤以单纯切除及定期复查为最好。
Flow cytometry was used to analyze DNA content and proliferative activity in 5 cases of congenital mesodermal nephroma, 96 cases of Wilms’ tumor and 27 cases of normal renal paraffin embedded tissues. At the same time for histological observation. The results showed that there were significant differences between nephroblastoma and nephroblastoma both in the presence of aneuploid cell peak, DI value, S% and PI value. Thus put forward the diagnosis of nephroblasto-1 type of diagnosis and congenital mesoderm nephroma phase identification. At the same time, the main causes of misdiagnosis in clinic were analyzed. Combined with follow-up that appear to DNA aneuploidy of congenital mesoderm kidney tumors with simple excision and regular review as the best.