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目的:研究养阴通络方对脑缺血损伤的保护作用。方法:在长期激怒法致肝肾阴虚证动物模型基础上,采用大鼠线栓法复制局灶性脑缺血再灌注模型,观察大鼠脑缺血再灌注损伤后神经症状评分、脑含水量、脑梗塞范围、脑组织病理形态的变化。采用小鼠断头致脑缺血模型,观察小鼠断头张口喘气时间。结果:养阴通络方16g/kg组能使缺血再灌注后大鼠的神经行为明显改善,明显降低脑梗塞率和含水量,可延长小鼠断头张口喘气时间;养阴通络方8g/kg组脑梗塞率明显降低。脑组织切片病理学检查表明养阴通络方对缺血再灌注损伤具有明显保护作用。结论:养阴通络方对脑缺血有保护作用。
Objective: To study the protective effects of Yangyin Tongluo Prescription on cerebral ischemia injury. Methods: On the basis of long-term anger induced liver and kidney yin deficiency syndrome model, focal cerebral ischemia / reperfusion model was induced by the method of thread occlusion in rats. Neurological symptom score, Water volume, extent of cerebral infarction, pathological changes of brain tissue. The mice were subjected to decapitation induced cerebral ischemia, and the mice were anesthetized. Results: Nourishing Yin Tongluo Prescription 16g / kg group can significantly improve the neurological behavior of rats after ischemia-reperfusion, significantly reduce the rate of cerebral infarction and water content, prolonged gasping time in mice with decapitation; Cerebral infarction rate in 8g / kg group decreased significantly. Pathological examination of brain tissue sections showed that Yangyin Tongluo Formula had obvious protective effect on ischemia-reperfusion injury. Conclusion: Yangyin Tongluo Prescription has a protective effect on cerebral ischemia.