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目的旨在探究结肠癌患者行右结肠切除术中肠系膜上神经丛的损伤对患者肠功能及生活质量的影响。方法选择2014年1月至2016年12月时间段内至郑州人民医院就诊并明确诊断为“原发性右侧结肠癌”的患者为研究对象,总计96例,所有患者均行右结肠切除手术,按照是否予以延伸的肠系膜切除将研究对象分为研究组与对照组(各48例),术后通过腹泻评估量表(DAS)与胃肠道生活质量指数(GIQLI)评估患者的胃肠道功能和生活质量。结果研究组与对照组的研究对象在年龄、性别、结肠切除长度等方面相比均无统计学差异;研究组患者的排便频次显著增加,其他DAS评分项目上无显著差异;随访胃肠生活质量指数评分两组患者间无显著性差异;回归分析及对混杂因素进行矫正后显示对照组的肠频率分数低于观察组0.45,组间差异性显著(P=0.018);观察组内中结肠动脉起始位置近端存在空肠动脉病例的DAS评分及肠频率分数均较低,分别偏低1.82与0.68。结论本研究初步证实右结肠切除术内切除肠系膜上神经丛一定程度上能够增加肠运动频率,但对胃肠道相关的生活质量无显著影响。
The purpose of this study was to investigate the effect of injury of superior mesenteric plexus in patients with colon cancer on intestinal function and quality of life in patients undergoing right-colon resection. Methods Patients from January 2014 to December 2016 in Zhengzhou People’s Hospital who were diagnosed as “primary right colon cancer” were enrolled in this study. A total of 96 patients were selected. All patients underwent right colon The patients were divided into study group and control group (48 cases each) according to whether the mesenteric resection was performed or not. The patients’ stomach was evaluated by diarrhea assessment scale (DAS) and gastrointestinal quality of life index (GIQLI) Intestinal function and quality of life. Results There was no significant difference in the age, sex and length of resection between the study group and the control group. The frequency of defecation in the study group was significantly increased, but no significant difference was found in other DAS score items. The follow-up of gastrointestinal quality of life The regression analysis and the correction of confounding factors showed that the frequency of intestinal frequency in the control group was lower than that of the observation group (0.45), the difference was significant (P = 0.018); in the observation group, the middle colonic artery DAS scores and intestinal frequency scores of jejunal arteries in the proximal end of the initial location were lower, lower 1.82 and 0.68 respectively. Conclusions This study initially confirmed that resection of the superior mesenteric plexus in right-colon resection can increase the frequency of intestinal motility to some extent, but has no significant effect on the quality of life associated with the gastrointestinal tract.