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丝虫感染的化疗一直是不能令人满意的。卅多年前,Findlay叙述了寻找有效药物的工作,这些工作包括对碘、金、铜、锰、锌、铅、汞、砷和锑盐,吖啶类衍生物,吐酒石,眼镜蛇毒和苦味酸等化合物的研究。当时将治疗血吸虫病和利什曼病的锑剂用于人的淋巴丝虫病和盘尾丝虫病是有效的。斯锑波芬多年来用于治疗犬的犬恶丝虫病。Ashburn等证明锑剂对丝虫的子宫和卵巢的毒性与对血吸虫的相同。花青染料也有
Chemotherapy of filarial infections has been unsatisfactory.卅 Years ago, Findlay described the search for effective drugs that included the treatment of iodine, gold, copper, manganese, zinc, lead, mercury, arsenic and antimony salts, acridine derivatives, tartar, cobra venom and bitterness Acid and other compounds. At that time, antimony agents for treating schistosomiasis and leishmaniasis were effective for human lymphatic filariasis and onchocerciasis. Strobifen has been used to treat canine dysentery in many years. Ashburn et al. Demonstrated that antimony agents are equally toxic to filarial wombs and ovaries as they do to schistosomes. Cyan dyes are also available