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目的分析探讨中晚期宫颈鳞癌放化疗后复发未控相关因素,以改善患者的放化疗效果。方法选择我院2012年9月至2014年9月之间收治的中晚期宫颈鳞癌患者146例作为观察对象,其中有复发未控患者32例,无复发未控患者114例,分别为观察组和对照组。对两组患者的临床资料进行统计学分析,通过logistic软件进行多因素回归分析,掌握复发未控的相关因素。结果发生复发未控的患者32例,复发未控率为21.92%;通过单因素回归分析发现,患者肿瘤的分化程度、病灶的直径、之前之间的血红担保等指标之间存在差异;通过多因素回归发现,患者的肿瘤分化程度、直径≥4 cm、转移情况以及治疗前血红蛋白≤90 g/L等是中晚期宫颈癌患者出现复发未控的独立危险因素。结论中晚期宫颈癌患者复发未控的独立危险因素主要有肿瘤分化程度、直径≥4 cm、转移情况以及治疗前血红蛋白≤90 g/L等,应当根据患者的实际情况,制定是针对性的方案,以达到最佳的效果。
Objective To analyze and analyze the factors related to the recurrence of advanced squamous cell carcinoma of the cervix after radiotherapy and chemotherapy in order to improve the radiotherapy and chemotherapy effect. Methods A total of 146 patients with advanced squamous cell carcinoma of the cervix who were treated in our hospital from September 2012 to September 2014 were selected as the observation subjects. Among them, there were 32 patients with uncontrollable recurrence and 114 patients without recurrence, which were respectively observation group And control group. The clinical data of two groups of patients were statistically analyzed by multivariate regression analysis of logistic software to grasp the relapse of uncontrolled factors. Results There were 32 patients with uncontrollable recurrence and 21.92% of them were uncontrolled recurrence rate. By univariate regression analysis, it was found that there was a difference between tumor differentiation, diameter of lesion, Factors regression found that the degree of tumor differentiation, diameter ≥ 4 cm, metastasis and pretreatment hemoglobin ≤ 90 g / L is an independent risk factor for recurrence of advanced cervical cancer patients. Conclusion The independent risk factors of recurrence of advanced cervical cancer patients are tumor differentiation, diameter ≥ 4 cm, metastasis and pretreatment hemoglobin ≤ 90 g / L, etc., should be based on the actual situation of patients, to develop a targeted program , In order to achieve the best results.