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一氧化氮(NO)吸入可以选择性降低肺动脉压,有效提高ARDS患者的气体交换,静脉注射前列腺素可产生非选择性血管扩张作用。为了观察经支气管雾化吸入前列腺素对ARDS患者血液动力学与气体交换的影响,作者比较了NO与PGI_2吸入对ARDS患者的影响。 选择的16例患者均符合近期美欧共同会议确定的ARDS诊断标准,平均PaO_2/FiO_2为114±12mmHg,肺损伤值为2.75±0.05,9例伴有多脏器损害,总体生存率为56％,所有患者都使用了机械通气,采用容量控制模式,包括PEEP和反比通气,吸气峰压
Nitric oxide (NO) inhalation can selectively reduce pulmonary artery pressure, effectively improve the gas exchange in patients with ARDS, intravenous injection of prostaglandin can produce non-selective vasodilation. To investigate the effect of bronchial inhalation of prostaglandins on hemodynamics and gas exchange in patients with ARDS, we compared the effects of inhaled NO and PGI 2 on patients with ARDS. The selected 16 patients were in line with the recent ARDS diagnostic criteria of the United States and Europe, the average PaO_2 / FiO_2 114 ± 12mmHg, lung damage was 2.75 ± 0.05, 9 cases were associated with multiple organ damage, the overall survival rate was 56% , All patients underwent mechanical ventilation using a volume control mode including PEEP and inverse gas, peak inspiratory pressure