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目的探讨中西医结合治疗胎儿生长受限(FGR)的临床疗效及安全性。方法选择FGR患者152例,分成二组,治疗组74例采用右旋糖酐40、丹参针注射液联用中药制剂治疗,对照组78例用右旋糖酐40、丹参针注射液治疗。观察二组治疗前后及终止妊娠前胎儿生长情况、羊水指数、胎儿生理物理评分、中西药对孕妇凝血功能影响、新生儿情况并进行随访。结果治疗组每周宫高增长(0.7±0.4)cm;高于对照组(0.5±0.6)cm,每周双顶径增长(2.4±0.7)cm,高于对照组(1.7±0.6)cm;治疗组、对照组生物物理评分分别为(9.7±0.8)分、(8.9±0.7)分,差异有统计学意义;治疗组新生儿1min Apgar评分8~10分,占86%,高于对照组74%;新生儿体重为(3 100±256)g,高于对照组(2 580±304)g;胎龄(38±4)周,长于对照组(37±4)周。以上各观察指标治疗组均高于对照组(P<0.05)。结论中西医结合治疗FGR可改善胎盘血流,使胎儿体重增加,改善围生儿预后,对母儿都安全。
Objective To investigate the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of fetal growth restriction (FGR). Methods Fifty-two patients with FGR were selected and divided into two groups. The treatment group received dextran 40 and Danshen acupuncture combined with traditional Chinese medicine. In the control group, 78 cases were treated with dextran 40 and Danshen acupuncture injection. Before and after treatment and before termination of pregnancy, fetal growth, amniotic fluid index, physical and physical score of fetus, coagulation function of Chinese and western medicine on pregnant women and newborns were observed and followed up. Results The average growth rate of the treatment group was (0.7 ± 0.4) cm per week, higher than that of the control group (0.5 ± 0.6 cm), and the weekly biparietal diameter was (2.4 ± 0.7) cm higher than that of the control group (1.7 ± 0.6 cm) The biophysical scores of the treatment group and the control group were (9.7 ± 0.8) and (8.9 ± 0.7) points, respectively, with significant difference. The Apgar score of the neonates in the treatment group was 8-10 (86%) at 1 minute, which was higher than that of the control group The newborn’s body weight was (3 100 ± 256) g, which was higher than that of the control group (2 580 ± 304) g. The gestational age was (38 ± 4) weeks longer than the control group (37 ± 4) weeks. The above indicators of the treatment group were higher than the control group (P <0.05). Conclusion Integrative treatment of FGR can improve placental blood flow, so that fetal weight gain, improve the prognosis of perinatal children, both mother and child are safe.