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目的为了探讨肝硬化患者在住院期间平均红细胞体积(MCV)、红细胞体积分布宽度(RDW)、血小板数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)的变化与病情关系及临床意义。方法选我院2008年1月开始到2009年10月住院肝硬化患者共50例为观察组,正常体检者50例为对照组。应用SysmexKX-21型全自动血液分析仪测定血常规即平均红细胞体积(MCV)、红细胞体积分布宽度(RDW)、血小板(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)。结果肝硬化患者MCV、RDW、PDW显著高于对照组(P<0.01),PLT、MPV显著低于对照组(P<0.01)。MCV、RDW之间呈正相关,PLT、MPV之间呈正相关,PLT、MPV与PDW之间呈负相关。结论肝硬化患者MCV、RDW、PLT、MPV、PDW测定对肝硬化患者肝功能损害程度的初步评估和有无出血倾向的判断有重要意义。
Objective To investigate the relationship between changes of mean corpuscular volume (MCV), RDW, PLT, MPV and PDW in hospitalized patients with cirrhosis, Clinical significance. Methods Fifty patients with hospitalized cirrhosis in our hospital from January 2008 to October 2009 were selected as the observation group and 50 normal controls as the control group. Blood samples were collected for determination of hematology (MCV, RDW, PLT, MPV, PDW) using a Sysmex KX-21 automatic hematology analyzer. Results MCV, RDW and PDW in patients with cirrhosis were significantly higher than those in the control group (P <0.01). PLT and MPV were significantly lower than those in the control group (P <0.01). There was a positive correlation between MCV and RDW, PLT and MPV, but negative correlation between PLT, MPV and PDW. Conclusion The assessment of MCV, RDW, PLT, MPV and PDW in cirrhotic patients is of great significance in the preliminary assessment of the degree of liver damage and the determination of the tendency of bleeding in cirrhotic patients.