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本文报告经尸检证实的25例婴儿肝炎综合征。临床见有黄疸、肝脾肿大和肝功能异常;病理以肝细胞变性和灶性坏死,淋巴细胞为主的炎细胞浸润、胆汁淤积及间质结缔组织轻度增生等改变为主,其中6例在肝内找到巨细胞包涵体,1例有多核巨细胞形成。有关本病的临床和病理特点、分类及与胸腺萎缩的关系进行了重点讨论。
This article reports 25 autistic hepatitis syndromes confirmed by autopsy. Clinical jaundice, hepatosplenomegaly and abnormal liver function; pathological changes in hepatocyte degeneration and focal necrosis, inflammatory cell infiltration of lymphocytes, cholestasis and interstitial connective tissue mild hyperplasia and other changes in which 6 cases In the liver to find giant cell inclusion body, a case of multinucleated giant cell formation. The clinical and pathological features of this disease, classification and relationship with thymic atrophy were the focus of discussion.