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1979年以来,本协作组应用南京生化制药厂研制的由正常猪肝中提取的核糖核酸(以下简称RNA)治疗慢性肝炎及肝硬化共306例,取得一定的疗效,总结如下。病例选择本组所选治的病例包括:慢性迁延性肝炎62例,病期为6月～12年;慢性活动性肝炎169例,病期为1～16年;肝炎肝硬化(代偿期病例为主)75例,自诊断肝硬化后的病期为3月～10年余。男261例,女45例。均为成年患者,年龄17～65岁,其中20～49岁的青壮年229例,占74.8％。于应用 RNA治疗前,所有患者都用过其他中、西药物治疗,但疗效不满意,肝功能长期持续或反复异常。治疗和观察方法RNA系冻干制剂。剂量为每次6毫克,肌肉注射,隔日一次。疗程为2月154例,2~+～3月119例,3~+～4月27例,4~+～6月6例。大多数患者除酌予配合应用维生素B、C和干酵母
Since 1979, our group has applied 306 cases of chronic hepatitis and liver cirrhosis extracted from normal porcine liver extracted from normal porcine liver (hereinafter referred to as RNA) developed by Nanjing Biochemical Pharmaceutical Factory, and achieved some curative effects, which are summarized as follows. Case Selection The group of patients selected for treatment include: 62 cases of chronic persistent hepatitis, the disease period of 6 months to 12 years; 169 cases of chronic active hepatitis, the disease period of 1 to 16 years; hepatitis cirrhosis (compensated cases Mainly) 75 cases, since the diagnosis of cirrhosis of the disease period of 3 months to more than 10 years. There were 261 males and 45 females. All adult patients, aged 17 to 65 years, of which 20 to 49 years of young and middle-aged 229 cases, accounting for 74.8%. Before the application of RNA therapy, all patients had used other Chinese and Western drug treatment, but the effect is not satisfied, long-term persistent or recurrent liver abnormalities. Treatment and Observation Methods RNA is a lyophilized preparation. The dose of 6 mg each time, intramuscular injection, every other day. The course of treatment was 154 cases in February, 119 cases in 2 ~ + ~ 3 months, 27 cases in 3 ~ + ~ 4 months and 6 cases in 4 ~ + ~ 6 months. Most patients except for the use of vitamin B, C and dry yeast