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目的:观察利用专利技术特别制造的微波腔内辐射器进行手术前热疗联合放射治疗ⅠB2期子宫颈癌患者的近期临床疗效和毒副反应。方法:全部病例均为ⅠB2期子宫颈鳞状细胞癌患者,术前给予腔内微波热疗联合近距离放射治疗(热放组)23例与单纯术前近距离放射治疗(单放组)33例进行比较。采用192Ir源后装近距离照射,每次给予A点5Gy,每周2次,共4次;热疗采用腔内加热的方法,肿瘤表面温度达44.5℃并持续45min,共4次。全部患者在完成放射治疗的2周后接受子宫颈癌根治术和盆腔淋巴结清除术。结果:热放组与单放组局部反应率(PR)分别为91.3%和63.6%,血清鳞状上皮癌抗原(SCC-Ag)水平下降分别为87.0%和57.6%,两者差异均有统计学意义,P<0.05;直肠反应和膀胱反应在两组之间差异无统计学意义,P>0.05。结论:腔内微波热疗联合放射治疗ⅠB2期子宫颈癌可以获得较单纯放射治疗更高的局部反应率以及鳞状上皮癌抗原(SCC-Ag)明显下降,近期的毒副反应无显著增加。可以进行更深入的临床研究。
OBJECTIVE: To observe the short-term clinical efficacy and side effects of pre-operative hyperthermia combined with radiotherapy for stage IIB2 cervical cancer using patented microwave-made cavity radiators. Methods: All cases were stage ⅠB2 cervical squamous cell carcinoma patients. 23 cases were treated with intracavitary microwave hyperthermia combined with brachytherapy (heat-release group) and 33 cases with preoperative brachytherapy alone Example for comparison. After using 192Ir source installed close range irradiation, each given A point 5Gy, 2 times a week for a total of 4 times; hyperthermia using lumen heating method, the tumor surface temperature reached 44.5 ℃ and lasted 45min, a total of 4 times. All patients underwent radical mastectomy and pelvic lymphadenectomy 2 weeks after completing radiotherapy. Results: The partial response rate (PR) in radiotherapy group and radiotherapy alone group were 91.3% and 63.6% respectively, and the levels of serum SCC-Ag were decreased by 87.0% and 57.6%, respectively Significance, P <0.05; rectal response and bladder reaction in the two groups, the difference was not statistically significant, P> 0.05. Conclusions: Intra-cavity microwave hyperthermia combined with radiotherapy for stage IIB cervical cancer can achieve a higher local response rate and SCC-Ag than radiotherapy alone, with no significant increase in the recent side effects. More in-depth clinical studies are possible.