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应用固相酶联免疫测定方法(ELISA)检测了100例各类肝病患者血清抗-HCV及输血后肝炎抗-HCV阳性患者红细胞免疫、T细胞亚群。结果,100例中共发现36例(36％)血清抗-HCV阳性,慢性乙型肝炎45例中6例(13％)抗-HCV阳性,肝硬化18例(其中HBsAg阳性15例,同时抗HCV阳性者5例)中6例抗-HCV阳性,非甲非乙型肝炎37例中24例(其中散发性肝炎11例,4例抗-HCV阳性占36％,输血或输血制品后肝炎26例中20例抗-HCV阳性,占75％)抗-HCV阳性。另外,输血后肝炎抗-HCV阳性者红细胞免疫功能较正常对照组明显低下(P<0.01),红细胞免疫粘附促进因子降低(P<0.01),抑制因子增高(P<0.01),外周血CD_3比正常对照组无明显变化(P>0.05),CD_4明显下降(P<0.01),CD_8无明显差异(P>0.05),CD_4/CD_8比值明显下降(P<0.01)。
Erythrocyte immune and T lymphocyte subsets in serum of anti-HCV and anti-HCV positive patients after transfusion of hepatitis B were detected by enzyme-linked immunosorbent assay (ELISA). As a result, 36 cases (36%) were found to have anti-HCV positive serum in 100 cases, 6 cases (13%) of chronic hepatitis B were anti-HCV positive and 18 cases of cirrhosis (15 cases were HBsAg positive, Positive in 5 cases) 6 cases of anti-HCV-positive, 37 cases of non-A non-B hepatitis in 24 cases (including 11 cases of sporadic hepatitis, 4 cases of anti-HCV positive accounted for 36%, transfusions or blood transfusions in 26 cases of hepatitis 20 cases of anti-HCV positive, accounting for 75%) anti-HCV positive. In addition, erythrocyte immune function of anti-HCV positive patients with hepatitis B after transfusion was significantly lower than that of normal control group (P <0.01), erythrocyte immune adhesion promoting factor (P <0.01), inhibitory factor increased Compared with the normal control group, there was no significant change (P> 0.05). CD_4 decreased significantly (P <0.01), CD_8 showed no significant difference (P> 0.05), and CD_4 / CD_8 ratio decreased significantly.