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以聚乙烯吡咯烷酮(PVP K30)为载体,利用喷雾干燥法制备染料木素(1)的固体分散体。采用X射线粉末衍射(XRPD)、差示扫描量热分析(DSC)和激光粒度分析(LD-PSD)对制品进行表征。结果表明,1在固体分散体中均以无定形或分子状态存在。所制备的1-PVP K30(1∶5,w/w)固体分散体平均粒径为(8.9±1.1)?m,在pH 6.8缓冲液中不但可显著提高1的溶解度至8.37 mg/ml,而且可使1在2 h内完全溶出;此外,在25℃/相对湿度60%条件下放置2个月,物理和化学稳定性较好。
A solid dispersion of genistein (1) was prepared by spray drying using polyvinylpyrrolidone (PVP K30) as a carrier. The products were characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and laser particle size analysis (LD-PSD). The results show that 1 are both amorphous or molecular state in the solid dispersion. The average particle size of the prepared 1-PVP K30 (1: 5, w / w) solid dispersion was (8.9 ± 1.1) μm and not only increased the solubility of 1 to 8.37 mg / ml in pH 6.8 buffer, In addition, 1 can be completely dissolved within 2 h. In addition, it has good physical and chemical stability when left for 2 months at 25 ° C / 60% relative humidity.