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本研究在国内率先采用新生猪作缺氧缺血性脑损伤动物模型，建立了墨汁灌注脑血流量测定的新方法。从多方面对新生儿ＨＩＥ进行了广泛深入的研究。结果发现：脑血流减少，细胞内钙超载，氧自由基、兴奋性氨基酸及前列腺素代谢产物的增加与ＨＩＥ的发生及严重程度密切相关。血和
In this study, we took the lead in using the newborn pig as an animal model of hypoxic-ischemic brain damage and established a new method of measuring the cerebral perfusion of ink. In many aspects of neonatal HIE conducted extensive and in-depth study. The results showed that the decrease of cerebral blood flow, the intracellular calcium overload, the increase of oxygen free radicals, excitatory amino acids and prostaglandin metabolites were closely related to the occurrence and severity of HIE. Blood and