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目的 研究乌鲁木齐市老年人群载脂蛋白E(ApoE)基因与脑梗死 (CI)和心肌梗死 (MI)之间的相关性。方法 应用聚合酶链式反应扩增技术及限制性片段长度多态性技术对 5 6例脑梗死患者、60例心肌梗死患者及 10 4例对照者的ApoE基因进行分型 ,分别计算各组ApoE等位基因、基因型的频率。结果 脑梗死组和心肌梗死组ε3 /ε4、ε4/ε4基因型频率明显高于对照组 (P <0 0 5 ) ,ε2 /ε2基因型频率明显低于对照组 (P <0 0 5 ) ;脑梗死组的ApoEε4等位基因频率明显高于对照组 (P <0 0 5 ) ;ApoE基因多态与心肌梗死间未发现关联。结论ApoEε4等位基因可能是脑梗死潜在的危险因子 ,ε2等位基因对脑梗死的发生可能具有一定保护作用。
Objective To investigate the relationship between ApoE gene and cerebral infarction (CI) and myocardial infarction (MI) in the elderly population in Urumqi. Methods Polymerase chain reaction amplification and restriction fragment length polymorphism were used to genotype ApoE gene in 56 patients with cerebral infarction, 60 patients with myocardial infarction and 104 controls. ApoE Allele, genotype frequency. Results The frequencies of ε3 / ε4 and ε4 / ε4 genotypes in cerebral infarction group and myocardial infarction group were significantly higher than those in control group (P <0.05). The frequency of ε2 / ε2 genotype was significantly lower than that in control group (P <0.05). The frequency of ApoEε4 allele in cerebral infarction group was significantly higher than that in control group (P <0.05). No association was found between ApoE gene polymorphism and myocardial infarction. Conclusion ApoEε4 allele may be a potential risk factor for cerebral infarction, ε2 allele may have a protective effect on the occurrence of cerebral infarction.