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通过几种化疗药物对C6胶质瘤细胞的药敏实验 ,观察化疗药物加增敏剂 (NMD)后 ,单独化疗和联合化疗药物的敏感性 ,为临床提供有效的治疗依据 .利用体外细胞培养 ,采用MTT和3H -TDR方法 ,分别测定几种化疗药物单独使用和联合使用对肿瘤的抑制率 .BCNU ,Vm - 2 6两种化疗药物联合使用加增敏剂 ,使药物浓度降低了 10 0倍 ,其对细胞的抑制率可达 97 0 4% .高于BCNU +NMD的抑制效果 ,也明显高于Vm - 2 6+NMD的抑瘤效果 .联合用药优于单独用药 ,具有低浓度、低毒、高效的作用 ,同时也增加了药物对瘤组织的抑制作用 .说明联合用药 ,具有协同和相加作用
The susceptibility testing of C6 glioma cells by several chemotherapeutic agents and the sensitivity of chemotherapy alone and chemotherapeutic agents after chemotherapeutic agents plus sensitizers (NMD) were used to provide an effective therapeutic basis for clinical use. In vitro cell culture Using MTT and 3H-TDR methods to determine the inhibition rate of several chemotherapeutic agents used alone and in combination. BCNU and Vm-26 combined use of chemotherapeutics plus sensitizers reduced the drug concentration by 10%. Times, the inhibition rate of the cells up to 97 0 4%. Higher than the inhibition effect of BCNU + NMD, but also significantly higher than the tumor inhibition effect of Vm - 26 + NMD. Combination therapy is better than using drugs alone, with low concentrations, Low toxicity and high efficacy, but also increase the inhibitory effect of drugs on the tumor tissue. Shows that the combination of drugs, with a synergistic and additive effect